Title |
A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma
|
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Published in |
Molecular Cancer, July 2014
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DOI | 10.1186/1476-4598-13-168 |
Pubmed ID | |
Authors |
Abdul K Siraj, Rong Bu, Sarita Prabhakaran, Prashant Bavi, Shaham Beg, Mohsen Al Hazmi, Maha Al-Rasheed, Khadija Alobaisi, Fouad Al-Dayel, Hadeel AlManea, Nasser Al-Sanea, Shahab Uddin, Khawla S Al-Kuraya |
Abstract |
Recent studies emphasize the role of BRAF as a genetic marker for prediction, prognosis and risk stratification in colorectal cancer. Earlier studies have reported the incidence of BRAF mutations in the range of 5-20% in colorectal carcinomas (CRC) and are predominantly seen in the serrated adenoma-carcinoma pathway characterized by microsatellite instability (MSI-H) and hypermethylation of the MLH1 gene in the setting of the CpG island methylator phenotype (CIMP). Due to the lack of data on the true incidence of BRAF mutations in Saudi Arabia, we sought to analyze the incidence of BRAF mutations in this ethnic group. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Saudi Arabia | 17 | 47% |
United States | 1 | 3% |
Unknown | 18 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 31 | 86% |
Practitioners (doctors, other healthcare professionals) | 3 | 8% |
Scientists | 1 | 3% |
Unknown | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 16% |
Student > Master | 7 | 13% |
Other | 5 | 9% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 4 | 7% |
Other | 12 | 22% |
Unknown | 14 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 38% |
Biochemistry, Genetics and Molecular Biology | 10 | 18% |
Computer Science | 3 | 5% |
Agricultural and Biological Sciences | 2 | 4% |
Chemistry | 2 | 4% |
Other | 0 | 0% |
Unknown | 17 | 31% |