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Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture

Overview of attention for article published in Proteome Science, July 2014
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2 X users

Citations

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116 Mendeley
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Title
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture
Published in
Proteome Science, July 2014
DOI 10.1186/1477-5956-12-39
Pubmed ID
Authors

Uros Rajcevic, Jaco C Knol, Sander Piersma, Sébastien Bougnaud, Fred Fack, Eirik Sundlisaeter, Karl Søndenaa, Reidar Myklebust, Thang V Pham, Simone P Niclou, Connie R Jiménez

Abstract

Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than commonly used 2D and 3D cell line models. Such structures harbour tumorigenic cells, as revealed by xenograft implantation studies in animal models and maintain the genetic makeup of the original tumor material. The aim of our work was a morphological and proteomic characterization of organotypic spheroids derived from colorectal cancer tissue in order to get insight into their composition and associated biology.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 <1%
United Kingdom 1 <1%
France 1 <1%
Luxembourg 1 <1%
Unknown 112 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 30%
Researcher 25 22%
Professor 9 8%
Student > Bachelor 9 8%
Student > Doctoral Student 8 7%
Other 17 15%
Unknown 13 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 22%
Agricultural and Biological Sciences 21 18%
Medicine and Dentistry 11 9%
Engineering 9 8%
Chemistry 8 7%
Other 22 19%
Unknown 20 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2014.
All research outputs
#17,723,043
of 22,758,248 outputs
Outputs from Proteome Science
#124
of 190 outputs
Outputs of similar age
#153,631
of 226,417 outputs
Outputs of similar age from Proteome Science
#2
of 2 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 190 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,417 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.