Title |
New strategy to control cell migration and metastasis regulated by CCN2/CTGF
|
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Published in |
Cancer Cell International, July 2014
|
DOI | 10.1186/1475-2867-14-61 |
Pubmed ID | |
Authors |
Diego Pinheiro Aguiar, Gabriel Correa de Farias, Eduardo Branco de Sousa, Juliana de Mattos Coelho-Aguiar, Julie Calixto Lobo, Priscila Ladeira Casado, Maria Eugênia Leite Duarte, José Garcia Ribeiro Abreu |
Abstract |
Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 3% |
Belgium | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 18% |
Student > Ph. D. Student | 6 | 18% |
Student > Doctoral Student | 4 | 12% |
Other | 4 | 12% |
Student > Master | 3 | 9% |
Other | 6 | 18% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 32% |
Medicine and Dentistry | 9 | 26% |
Agricultural and Biological Sciences | 3 | 9% |
Computer Science | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 24% |