Title |
Prognostic impact of MGMT promoter methylation and MGMT and CD133 expression in colorectal adenocarcinoma
|
---|---|
Published in |
BMC Cancer, July 2014
|
DOI | 10.1186/1471-2407-14-511 |
Pubmed ID | |
Authors |
Jaime Antonio Oliver, Raúl Ortiz, Consolación Melguizo, Pablo Juan Álvarez, Jaime Gómez-Millán, Jose Prados |
Abstract |
New biomarkers are needed for the prognosis of advanced colorectal cancer, which remains incurable by conventional treatments. O6-methylguanine DNA methyltransferase (MGMT) methylation and protein expression have been related to colorectal cancer treatment failure and tumor progression. Moreover, the presence in these tumors of cancer stem cells, which are characterized by CD133 expression, has been associated with chemoresistance, radioresistance, metastasis, and local recurrence. The objective of this study was to determine the prognostic value of CD133 and MGMT and their possible interaction in colorectal cancer patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 2% |
Unknown | 43 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 18% |
Researcher | 8 | 18% |
Student > Bachelor | 5 | 11% |
Professor > Associate Professor | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 6 | 14% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 23% |
Medicine and Dentistry | 9 | 20% |
Agricultural and Biological Sciences | 5 | 11% |
Nursing and Health Professions | 2 | 5% |
Arts and Humanities | 1 | 2% |
Other | 1 | 2% |
Unknown | 16 | 36% |