Title |
The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis
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Published in |
Inflammation and Regeneration, September 2017
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DOI | 10.1186/s41232-017-0050-9 |
Pubmed ID | |
Authors |
Tadayoshi Karasawa, Masafumi Takahashi |
Abstract |
Atherosclerosis is an inflammatory disease, which is accompanied by the deposition of cholesterol-rich lipids and the infiltration of macrophages. Other well-known features of atherosclerotic lesions include the deposition of cholesterol crystals and calcium phosphate crystals; however, their pathophysiological role remains unclear. Recent studies suggest that cholesterol crystals play a pivotal role in activation of NLRP3 inflammasomes, which regulate caspase-1 activation and the subsequent processing of IL-1β, in atherosclerotic lesions. NLRP3 inflammasomes are essential for the initiation of vascular inflammation during the progression of atherosclerosis. Therefore, the regulatory mechanisms of NLRP3 inflammasomes are regarded as potential targets for atherosclerosis treatment. Here, we review the current knowledge regarding the role of NLRP3 inflammasomes in the progression of atherosclerosis and the prospects for therapeutic approaches targeting NLRP3 inflammasomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Singapore | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 40% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Scientists | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 27% |
Researcher | 9 | 14% |
Student > Master | 8 | 13% |
Student > Doctoral Student | 3 | 5% |
Student > Bachelor | 2 | 3% |
Other | 7 | 11% |
Unknown | 17 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 17% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Agricultural and Biological Sciences | 7 | 11% |
Immunology and Microbiology | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 4 | 6% |
Unknown | 24 | 38% |