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Cannabinoid-Mediated Modulation of Neuropathic Pain and Microglial Accumulation in a Model of Murine Type I Diabetic Peripheral Neuropathic Pain

Overview of attention for article published in Molecular Pain, January 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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11 X users

Citations

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125 Dimensions

Readers on

mendeley
173 Mendeley
citeulike
1 CiteULike
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1 Connotea
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Title
Cannabinoid-Mediated Modulation of Neuropathic Pain and Microglial Accumulation in a Model of Murine Type I Diabetic Peripheral Neuropathic Pain
Published in
Molecular Pain, January 2010
DOI 10.1186/1744-8069-6-16
Pubmed ID
Authors

Cory C Toth, Nicole M Jedrzejewski, Connie L Ellis, William H Frey

Abstract

Despite the frequency of diabetes mellitus and its relationship to diabetic peripheral neuropathy (DPN) and neuropathic pain (NeP), our understanding of underlying mechanisms leading to chronic pain in diabetes remains poor. Recent evidence has demonstated a prominent role of microglial cells in neuropathic pain states. One potential therapeutic option gaining clinical acceptance is the cannabinoids, for which cannabinoid receptors (CB) are expressed on neurons and microglia. We studied the accumulation and activation of spinal and thalamic microglia in streptozotocin (STZ)-diabetic CD1 mice and the impact of cannabinoid receptor agonism/antagonism during the development of a chronic NeP state. We provided either intranasal or intraperitoneal cannabinoid agonists/antagonists at multiple doses both at the initiation of diabetes as well as after establishment of diabetes and its related NeP state.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
United States 3 2%
Italy 1 <1%
Turkey 1 <1%
Spain 1 <1%
Norway 1 <1%
Unknown 163 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 17%
Researcher 26 15%
Student > Bachelor 20 12%
Student > Master 16 9%
Student > Postgraduate 10 6%
Other 35 20%
Unknown 37 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 19%
Medicine and Dentistry 30 17%
Neuroscience 15 9%
Pharmacology, Toxicology and Pharmaceutical Science 9 5%
Psychology 8 5%
Other 34 20%
Unknown 44 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2021.
All research outputs
#4,524,477
of 25,374,917 outputs
Outputs from Molecular Pain
#81
of 669 outputs
Outputs of similar age
#24,872
of 172,634 outputs
Outputs of similar age from Molecular Pain
#5
of 30 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,634 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.