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Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships

Overview of attention for article published in BMC Ecology and Evolution, January 2010
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Title
Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships
Published in
BMC Ecology and Evolution, January 2010
DOI 10.1186/1471-2148-10-26
Pubmed ID
Authors

Kathryn E Bushley, B Gillian Turgeon

Abstract

Nonribosomal peptide synthetases (NRPSs) are multimodular enzymes, found in fungi and bacteria, which biosynthesize peptides without the aid of ribosomes. Although their metabolite products have been the subject of intense investigation due to their life-saving roles as medicinals and injurious roles as mycotoxins and virulence factors, little is known of the phylogenetic relationships of the corresponding NRPSs or whether they can be ranked into subgroups of common function. We identified genes (NPS) encoding NRPS and NRPS-like proteins in 38 fungal genomes and undertook phylogenomic analyses in order to identify fungal NRPS subfamilies, assess taxonomic distribution, evaluate levels of conservation across subfamilies, and address mechanisms of evolution of multimodular NRPSs. We also characterized relationships of fungal NRPSs, a representative sampling of bacterial NRPSs, and related adenylating enzymes, including alpha-aminoadipate reductases (AARs) involved in lysine biosynthesis in fungi.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 257 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Denmark 2 <1%
Brazil 1 <1%
United Kingdom 1 <1%
France 1 <1%
New Zealand 1 <1%
Germany 1 <1%
Canada 1 <1%
Mexico 1 <1%
Other 0 0%
Unknown 243 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 24%
Researcher 49 19%
Student > Bachelor 29 11%
Student > Master 26 10%
Student > Doctoral Student 15 6%
Other 37 14%
Unknown 39 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 124 48%
Biochemistry, Genetics and Molecular Biology 55 21%
Chemistry 11 4%
Immunology and Microbiology 6 2%
Pharmacology, Toxicology and Pharmaceutical Science 3 1%
Other 10 4%
Unknown 48 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2012.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from BMC Ecology and Evolution
#2,929
of 3,714 outputs
Outputs of similar age
#142,849
of 172,175 outputs
Outputs of similar age from BMC Ecology and Evolution
#34
of 41 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.