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Friedreich ataxia: metal dysmetabolism in dorsal root ganglia

Overview of attention for article published in Acta Neuropathologica Communications, June 2013
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Title
Friedreich ataxia: metal dysmetabolism in dorsal root ganglia
Published in
Acta Neuropathologica Communications, June 2013
DOI 10.1186/2051-5960-1-26
Pubmed ID
Authors

Arnulf H Koeppen, Erik C Kuntzsch, Sarah T Bjork, R Liane Ramirez, Joseph E Mazurkiewicz, Paul J Feustel

Abstract

Friedreich ataxia (FA) causes distinctive lesions of dorsal root ganglia (DRG), including neuronal atrophy, satellite cell hyperplasia, and absorption of dying nerve cells into residual nodules. Two mechanisms may be involved: hypoplasia of DRG neurons from birth and superimposed iron (Fe)- and zinc (Zn)-mediated oxidative injury. This report presents a systematic analysis of DRG in 7 FA patients and 13 normal controls by X-ray fluorescence (XRF) of polyethylene glycol-embedded DRG; double-label confocal immunofluorescence microscopy of Zn- and Fe-related proteins; and immunohistochemistry of frataxin and the mitochondrial marker, ATP synthase F1 complex V β-polypeptide (ATP5B).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 20%
Professor > Associate Professor 9 18%
Other 6 12%
Student > Bachelor 4 8%
Professor 4 8%
Other 11 22%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 29%
Biochemistry, Genetics and Molecular Biology 12 24%
Medicine and Dentistry 11 22%
Neuroscience 3 6%
Physics and Astronomy 1 2%
Other 1 2%
Unknown 7 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2014.
All research outputs
#20,233,066
of 22,758,963 outputs
Outputs from Acta Neuropathologica Communications
#1,300
of 1,369 outputs
Outputs of similar age
#172,390
of 196,886 outputs
Outputs of similar age from Acta Neuropathologica Communications
#40
of 40 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,886 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.