Title |
Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast
|
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Published in |
BMC Microbiology, July 2014
|
DOI | 10.1186/1471-2180-14-188 |
Pubmed ID | |
Authors |
Naoyuki Togashi, Akira Yamashita, Masamitsu Sato, Masayuki Yamamoto |
Abstract |
Meiotic cells undergo two rounds of nuclear division and generate gametes. Previous studies have indicated that a number of transcription factors modulate the transcriptome in successive waves during meiosis and spore formation in fission yeast. However, the mechanisms underlying the post-transcriptional regulation in meiosis are not fully understood. The fission yeast spo5+ gene encodes a meiosis-specific RNA-binding protein, which is required for the progression of meiosis II and spore formation. However, the target RNA molecules of Spo5 are yet to be identified. Characterization of meiosis-specific RNA-binding proteins will provide insight into how post-transcriptional regulation influence gene expression during sexual differentiation. |
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