Title |
Positive effects of prolonged caloric restriction on the population of very small embryonic-like stem cells – hematopoietic and ovarian implications
|
---|---|
Published in |
Journal of Ovarian Research, June 2014
|
DOI | 10.1186/1757-2215-7-68 |
Pubmed ID | |
Authors |
Katarzyna Grymula, Katarzyna Piotrowska, Sylwia Słuczanowska-Głąbowska, Katarzyna Mierzejewska, Maciej Tarnowski, Marta Tkacz, Agata Poniewierska-Baran, Daniel Pędziwiatr, Ewa Suszyńska, Maria Laszczyńska, Mariusz Z Ratajczak |
Abstract |
Low calorie intake, or calorie restriction (CR) without malnutrition, has been demonstrated in several animal species, including mice, to increase both median and maximum lifespan as well as delay reproductive senescence. Our previous work demonstrated a positive correlation between life span and the number of very small embryonic-like stem cells (VSELs) in long living Laron dwarf mice. These animals have very low levels of circulating insulin-like growth factor 1 (IGF-1) in peripheral blood (PB), maintain higher numbers of hematopoietic stem cells (HSPCs) in bone marrow (BM), and display prolonged fecundity compared with wild type littermates. Since CR lowers the level of IGF-1 in PB, we become interested in the effect of CR on the number of VSELs and HSPCs in BM as well as on the morphology of ovaries and testes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
Ukraine | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 27% |
Other | 4 | 18% |
Student > Master | 4 | 18% |
Student > Bachelor | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Other | 1 | 5% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 23% |
Agricultural and Biological Sciences | 5 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 18% |
Nursing and Health Professions | 2 | 9% |
Social Sciences | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 18% |