Title |
Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules
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Published in |
Arthritis Research & Therapy, July 2014
|
DOI | 10.1186/ar4614 |
Pubmed ID | |
Authors |
Omar Salem, Hong Tian Wang, Abdulrahman M Alaseem, Ovidiu Ciobanu, Insaf Hadjab, Rahul Gawri, John Antoniou, Fackson Mwale |
Abstract |
We previously showed that type X collagen, a marker of late stage chondrocyte hypertrophy (associated with endochondral ossification), is constitutively expressed by mesenchymal stem cells (MSCs) from osteoarthritis patients and this may be related to Naproxen (Npx), a nonsteroidal anti-inflammatory drug used for therapy. Hedgehog (HH) signaling plays an important role during the development of bone. We tested the hypothesis that Npx affected osteogenic differentiation of human MSCs through the expression of Indian hedgehog (IHH), Patched-1 (PTC1) and GLI family members GLI1, GLI2, GLI3 in vitro. |
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