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Development of targeted adjuvants for HIV-1 vaccines

Overview of attention for article published in AIDS Research and Therapy, September 2017
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Title
Development of targeted adjuvants for HIV-1 vaccines
Published in
AIDS Research and Therapy, September 2017
DOI 10.1186/s12981-017-0165-8
Pubmed ID
Authors

Jun Liu, Mario Ostrowski

Abstract

Finding new adjuvants is an integrated component of the efforts in developing an effective HIV-1 vaccine. Compared with traditional adjuvants, a modern adjuvant in the context of HIV-1 prevention would elicit a durable and potent memory response from B cells, CD8(+) T cells, and NK cells but avoid overstimulation of HIV-1 susceptible CD4(+) T cells, especially at genital and rectal mucosa, the main portals for HIV-1 transmission. We briefly review recent advances in the studies of such potential targeted adjuvants, focusing on three classes of molecules that we study: TNFSF molecules, TLRs agonists, and NODs agonists.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 19%
Student > Ph. D. Student 6 19%
Other 3 10%
Student > Master 3 10%
Student > Doctoral Student 2 6%
Other 3 10%
Unknown 8 26%
Readers by discipline Count As %
Immunology and Microbiology 7 23%
Agricultural and Biological Sciences 6 19%
Medicine and Dentistry 4 13%
Biochemistry, Genetics and Molecular Biology 3 10%
Environmental Science 1 3%
Other 2 6%
Unknown 8 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2017.
All research outputs
#20,446,373
of 23,001,641 outputs
Outputs from AIDS Research and Therapy
#500
of 556 outputs
Outputs of similar age
#276,066
of 315,999 outputs
Outputs of similar age from AIDS Research and Therapy
#18
of 18 outputs
Altmetric has tracked 23,001,641 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 556 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,999 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.