Title |
A peptide fragment from the human COX3 protein disrupts association of Mycobacterium tuberculosisvirulence proteins ESAT-6 and CFP10, inhibits mycobacterial growth and mounts protective immune response
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Published in |
BMC Infectious Diseases, July 2014
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DOI | 10.1186/1471-2334-14-355 |
Pubmed ID | |
Authors |
Sachin Kumar Samuchiwal, Sultan Tousif, Dhiraj Kumar Singh, Arun Kumar, Anamika Ghosh, Kuhulika Bhalla, Prem Prakash, Sushil Kumar, Maitree Bhattacharyya, Prashini Moodley, Gobardhan Das, Anand Ranganathan |
Abstract |
Tuberculosis (TB) is one of the most prevalent infectious diseases affecting millions worldwide. The currently available anti-TB drugs and vaccines have proved insufficient to contain this scourge, necessitating an urgent need for identification of novel drug targets and therapeutic strategies. The disruption of crucial protein-protein interactions, especially those that are responsible for virulence in Mycobacterium tuberculosis - for example the ESAT-6:CFP10 complex - are a worthy pursuit in this direction. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 2 | 4% |
India | 1 | 2% |
Unknown | 50 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 17% |
Student > Ph. D. Student | 8 | 15% |
Student > Master | 5 | 9% |
Student > Postgraduate | 3 | 6% |
Professor > Associate Professor | 3 | 6% |
Other | 8 | 15% |
Unknown | 17 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 23% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Immunology and Microbiology | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Engineering | 2 | 4% |
Other | 7 | 13% |
Unknown | 20 | 38% |