Title |
Weighted Interaction SNP Hub (WISH) network method for building genetic networks for complex diseases and traits using whole genome genotype data
|
---|---|
Published in |
BMC Systems Biology, March 2014
|
DOI | 10.1186/1752-0509-8-s2-s5 |
Pubmed ID | |
Authors |
Lisette JA Kogelman, Haja N Kadarmideen |
Abstract |
High-throughput genotype (HTG) data has been used primarily in genome-wide association (GWA) studies; however, GWA results explain only a limited part of the complete genetic variation of traits. In systems genetics, network approaches have been shown to be able to identify pathways and their underlying causal genes to unravel the biological and genetic background of complex diseases and traits, e.g., the Weighted Gene Co-expression Network Analysis (WGCNA) method based on microarray gene expression data. The main objective of this study was to develop a scale-free weighted genetic interaction network method using whole genome HTG data in order to detect biologically relevant pathways and potential genetic biomarkers for complex diseases and traits. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Norway | 1 | 1% |
Switzerland | 1 | 1% |
Unknown | 77 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 22% |
Student > Ph. D. Student | 16 | 20% |
Student > Master | 12 | 15% |
Student > Postgraduate | 5 | 6% |
Professor | 5 | 6% |
Other | 11 | 14% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 35% |
Biochemistry, Genetics and Molecular Biology | 14 | 17% |
Computer Science | 8 | 10% |
Medicine and Dentistry | 4 | 5% |
Mathematics | 2 | 2% |
Other | 7 | 9% |
Unknown | 18 | 22% |