Title |
Computational reconstruction of proteome-wide protein interaction networks between HTLV retroviruses and Homo sapiens
|
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Published in |
BMC Bioinformatics, July 2014
|
DOI | 10.1186/1471-2105-15-245 |
Pubmed ID | |
Authors |
Suyu Mei, Hao Zhu |
Abstract |
Human T-cell leukemia viruses (HTLV) tend to induce some fatal human diseases like Adult T-cell Leukemia (ATL) by targeting human T lymphocytes. To indentify the protein-protein interactions (PPI) between HTLV viruses and Homo sapiens is one of the significant approaches to reveal the underlying mechanism of HTLV infection and host defence. At present, as biological experiments are labor-intensive and expensive, the identified part of the HTLV-human PPI networks is rather small. Although recent years have witnessed much progress in computational modeling for reconstructing pathogen-host PPI networks, data scarcity and data unavailability are two major challenges to be effectively addressed. To our knowledge, no computational method for proteome-wide HTLV-human PPI networks reconstruction has been reported. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Puerto Rico | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 4% |
Brazil | 1 | 4% |
Unknown | 24 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 19% |
Student > Ph. D. Student | 5 | 19% |
Student > Master | 3 | 12% |
Other | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 5 | 19% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 27% |
Agricultural and Biological Sciences | 5 | 19% |
Computer Science | 5 | 19% |
Medicine and Dentistry | 2 | 8% |
Neuroscience | 1 | 4% |
Other | 0 | 0% |
Unknown | 6 | 23% |