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X Demographics
Mendeley readers
| Title |
Antibiotic rotation strategies to reduce antimicrobial resistance in Gram-negative bacteria in European intensive care units: study protocol for a cluster-randomized crossover controlled trial
|
|---|---|
| Published in |
Trials, July 2014
|
| DOI | 10.1186/1745-6215-15-277 |
| Pubmed ID | |
| Authors |
Pleun J van Duijn, Marc JM Bonten |
| Abstract |
Intensive care units (ICU) are epicenters for the emergence of antibiotic-resistant Gram-negative bacteria (ARGNB) because of high rates of antibiotic usage, rapid patient turnover, immunological susceptibility of acutely ill patients, and frequent contact between healthcare workers and patients, facilitating cross-transmission.Antibiotic stewardship programs are considered important to reduce antibiotic resistance, but the effectiveness of strategies such as, for instance, antibiotic rotation, have not been determined rigorously. Interpretation of available studies on antibiotic rotation is hampered by heterogeneity in implemented strategies and suboptimal study designs. In this cluster-randomized, crossover trial the effects of two antibiotic rotation strategies, antibiotic mixing and cycling, on the prevalence of ARGNB in ICUs are determined. Antibiotic mixing aims to create maximum antibiotic heterogeneity, and cycling aims to create maximum antibiotic homogeneity during consecutive periods. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Nepal | 1 | <1% |
| Panama | 1 | <1% |
| Unknown | 140 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 19% |
| Researcher | 19 | 13% |
| Student > Postgraduate | 12 | 8% |
| Student > Ph. D. Student | 12 | 8% |
| Student > Bachelor | 12 | 8% |
| Other | 30 | 21% |
| Unknown | 31 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 38% |
| Nursing and Health Professions | 11 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 8% |
| Biochemistry, Genetics and Molecular Biology | 7 | 5% |
| Agricultural and Biological Sciences | 5 | 3% |
| Other | 19 | 13% |
| Unknown | 36 | 25% |