Title |
Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
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Published in |
Molecular Cancer, July 2014
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DOI | 10.1186/1476-4598-13-174 |
Pubmed ID | |
Authors |
Christof Bernemann, Carolin Hülsewig, Christian Ruckert, Sarah Schäfer, Lena Blümel, Georg Hempel, Martin Götte, Burkhard Greve, Peter J Barth, Ludwig Kiesel, Cornelia Liedtke |
Abstract |
Triple negative breast cancer (TNBC) is characterized by lack of expression of both estrogen and progesterone receptor as well as lack of overexpression or amplification of HER2. Despite an increased probability of response to chemotherapy, many patients resistant to current chemotherapy regimens suffer from a worse prognosis compared to other breast cancer subtypes. However, molecular determinants of response to chemotherapy specific to TNBC remain largely unknown. Thus, there is a high demand for biomarkers potentially stratifying triple negative breast cancer patients for neoadjuvant chemotherapies or alternative therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 2% |
Belgium | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 48 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 18% |
Researcher | 8 | 16% |
Student > Bachelor | 7 | 14% |
Student > Ph. D. Student | 7 | 14% |
Student > Doctoral Student | 3 | 6% |
Other | 5 | 10% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 27% |
Biochemistry, Genetics and Molecular Biology | 9 | 18% |
Medicine and Dentistry | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Engineering | 2 | 4% |
Other | 7 | 14% |
Unknown | 13 | 25% |