Title |
Rapid screening for phenotype-genotype associations by linear transformations of genomic evaluations
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Published in |
BMC Bioinformatics, July 2014
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DOI | 10.1186/1471-2105-15-246 |
Pubmed ID | |
Authors |
Jose L Gualdrón Duarte, Rodolfo JC Cantet, Ronald O Bates, Catherine W Ernst, Nancy E Raney, Juan P Steibel |
Abstract |
Currently, association studies are analysed using statistical mixed models, with marker effects estimated by a linear transformation of genomic breeding values. The variances of marker effects are needed when performing the tests of association. However, approaches used to estimate the parameters rely on a prior variance or on a constant estimate of the additive variance. Alternatively, we propose a standardized test of association using the variance of each marker effect, which generally differ among each other. Random breeding values from a mixed model including fixed effects and a genomic covariance matrix are linearly transformed to estimate the marker effects. |
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Geographical breakdown
Country | Count | As % |
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Norway | 1 | 17% |
Puerto Rico | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
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Scientists | 4 | 67% |
Members of the public | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 1% |
United States | 1 | 1% |
Denmark | 1 | 1% |
Argentina | 1 | 1% |
Unknown | 83 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 23% |
Researcher | 20 | 23% |
Student > Master | 10 | 11% |
Student > Postgraduate | 5 | 6% |
Student > Doctoral Student | 5 | 6% |
Other | 11 | 13% |
Unknown | 16 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 46 | 53% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Computer Science | 6 | 7% |
Veterinary Science and Veterinary Medicine | 3 | 3% |
Medicine and Dentistry | 2 | 2% |
Other | 3 | 3% |
Unknown | 21 | 24% |