Title |
MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives
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Published in |
Infectious Agents and Cancer, July 2014
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DOI | 10.1186/1750-9378-9-24 |
Pubmed ID | |
Authors |
Carolina MM Amaral, Katerina Cetkovská, Ana PAD Gurgel, Marcus V Cardoso, Bárbara S Chagas, Sérgio SL Paiva Júnior, Rita de Cássia Pereira de Lima, Jacinto C Silva-Neto, Luiz AF Silva, Maria TC Muniz, Valdir Q Balbino, Antonio C Freitas |
Abstract |
The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphisms in this gene can interfere in the regulation of cellular proliferation. We evaluated whether MDM2 SNP309 (rs2278744) associated or not with the use of oral contraceptive can heighten susceptibility to development of cervical lesions in women HPV infected. |
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