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MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives

Overview of attention for article published in Infectious Agents and Cancer, July 2014
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Title
MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives
Published in
Infectious Agents and Cancer, July 2014
DOI 10.1186/1750-9378-9-24
Pubmed ID
Authors

Carolina MM Amaral, Katerina Cetkovská, Ana PAD Gurgel, Marcus V Cardoso, Bárbara S Chagas, Sérgio SL Paiva Júnior, Rita de Cássia Pereira de Lima, Jacinto C Silva-Neto, Luiz AF Silva, Maria TC Muniz, Valdir Q Balbino, Antonio C Freitas

Abstract

The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphisms in this gene can interfere in the regulation of cellular proliferation. We evaluated whether MDM2 SNP309 (rs2278744) associated or not with the use of oral contraceptive can heighten susceptibility to development of cervical lesions in women HPV infected.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 14%
Student > Doctoral Student 5 12%
Student > Master 5 12%
Researcher 5 12%
Student > Ph. D. Student 4 10%
Other 7 17%
Unknown 10 24%
Readers by discipline Count As %
Medicine and Dentistry 11 26%
Biochemistry, Genetics and Molecular Biology 6 14%
Agricultural and Biological Sciences 5 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Computer Science 2 5%
Other 3 7%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2014.
All research outputs
#18,375,064
of 22,758,963 outputs
Outputs from Infectious Agents and Cancer
#344
of 515 outputs
Outputs of similar age
#163,498
of 228,762 outputs
Outputs of similar age from Infectious Agents and Cancer
#9
of 10 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 515 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,762 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.