Title |
Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial
|
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Published in |
Reproductive Biology and Endocrinology, July 2014
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DOI | 10.1186/1477-7827-12-65 |
Pubmed ID | |
Authors |
Hanae Pons-Rejraji, Florence Brugnon, Benoit Sion, Salwan Maqdasy, Gerald Gouby, Bruno Pereira, Geoffroy Marceau, Anne-Sophie Gremeau, Joel Drevet, Genevieve Grizard, Laurent Janny, Igor Tauveron |
Abstract |
Recommendations for cardiovascular disease prevention advocate lowering both cholesterol and low-density lipoprotein cholesterol systemic levels, notably by statin intake. However, statins are the subject of questions concerning their impact on male fertility. This study aimed to evaluate, by a prospective pilot assay, the efficacy and the toxicity of a decrease of cholesterol blood levels, induced by atorvastatin on semen quality and sexual hormone levels of healthy, normocholesterolaemic and normozoospermic men. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 7 | 25% |
United States | 2 | 7% |
United Kingdom | 2 | 7% |
Mexico | 1 | 4% |
Canada | 1 | 4% |
Portugal | 1 | 4% |
Brazil | 1 | 4% |
Finland | 1 | 4% |
Venezuela, Bolivarian Republic of | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 20 | 71% |
Practitioners (doctors, other healthcare professionals) | 7 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Netherlands | 1 | 1% |
Canada | 1 | 1% |
Unknown | 81 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 17 | 20% |
Researcher | 7 | 8% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 6 | 7% |
Student > Ph. D. Student | 6 | 7% |
Other | 15 | 18% |
Unknown | 26 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
Agricultural and Biological Sciences | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Nursing and Health Professions | 2 | 2% |
Other | 4 | 5% |
Unknown | 38 | 45% |