Title |
Yukmijihwang-tang for the treatment of xerostomia in the elderly: study protocol for a randomized, double-blind, placebo-controlled, two-center trial
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Published in |
Trials, September 2013
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DOI | 10.1186/1745-6215-14-281 |
Pubmed ID | |
Authors |
Gajin Han, Jae-Woo Park, Seok-Jae Ko, Jihee Son, Jongki Seon, Juyeon Kim, Seulki Kim, Inkwon Yeo, Bongha Ryu, Jinsung Kim |
Abstract |
Xerostomia, a subjective sense of dry mouth, is not generally regarded a disease despite its high prevalence among the elderly, and therefore continues to impair affected patients' quality of life. In traditional Korean medicine, 'Yin-Deficiency' has been implicated in the pathogenesis of xerostomia among the elderly. Yukmijihwang-tang is a famous herbal prescription used to relieve 'Yin-Deficiency', and reportedly has antioxidant effects; therefore, it is postulated that Yukmijihwang-tang can be used to treat xerostomia in the elderly. However, to our knowledge, no clinical trial has been conducted on the effects of Yukmijihwang-tang on xerostomia. Thus, we designed a randomized clinical trial to investigate the effects and safety of Yukmijihwang-tang on xerostomia in the elderly. In addition, we will clarify the aforementioned assumption that 'Yin-Deficiency' is the major cause of xerostomia in the elderly by identifying a correlation between xerostomia and 'Yin-Deficiency'. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 55 | 100% |
Demographic breakdown
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Student > Master | 8 | 15% |
Student > Postgraduate | 7 | 13% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 4 | 7% |
Professor | 4 | 7% |
Other | 12 | 22% |
Unknown | 16 | 29% |
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Medicine and Dentistry | 18 | 33% |
Agricultural and Biological Sciences | 3 | 5% |
Engineering | 2 | 4% |
Psychology | 2 | 4% |
Nursing and Health Professions | 1 | 2% |
Other | 5 | 9% |
Unknown | 24 | 44% |