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Yukmijihwang-tang for the treatment of xerostomia in the elderly: study protocol for a randomized, double-blind, placebo-controlled, two-center trial

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Title
Yukmijihwang-tang for the treatment of xerostomia in the elderly: study protocol for a randomized, double-blind, placebo-controlled, two-center trial
Published in
Trials, September 2013
DOI 10.1186/1745-6215-14-281
Pubmed ID
Authors

Gajin Han, Jae-Woo Park, Seok-Jae Ko, Jihee Son, Jongki Seon, Juyeon Kim, Seulki Kim, Inkwon Yeo, Bongha Ryu, Jinsung Kim

Abstract

Xerostomia, a subjective sense of dry mouth, is not generally regarded a disease despite its high prevalence among the elderly, and therefore continues to impair affected patients' quality of life. In traditional Korean medicine, 'Yin-Deficiency' has been implicated in the pathogenesis of xerostomia among the elderly. Yukmijihwang-tang is a famous herbal prescription used to relieve 'Yin-Deficiency', and reportedly has antioxidant effects; therefore, it is postulated that Yukmijihwang-tang can be used to treat xerostomia in the elderly. However, to our knowledge, no clinical trial has been conducted on the effects of Yukmijihwang-tang on xerostomia. Thus, we designed a randomized clinical trial to investigate the effects and safety of Yukmijihwang-tang on xerostomia in the elderly. In addition, we will clarify the aforementioned assumption that 'Yin-Deficiency' is the major cause of xerostomia in the elderly by identifying a correlation between xerostomia and 'Yin-Deficiency'.

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The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 15%
Student > Postgraduate 7 13%
Student > Bachelor 4 7%
Student > Doctoral Student 4 7%
Professor 4 7%
Other 12 22%
Unknown 16 29%
Readers by discipline Count As %
Medicine and Dentistry 18 33%
Agricultural and Biological Sciences 3 5%
Engineering 2 4%
Psychology 2 4%
Nursing and Health Professions 1 2%
Other 5 9%
Unknown 24 44%