Title |
Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Medellín, Colombia
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Published in |
Hereditary Cancer in Clinical Practice, April 2014
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DOI | 10.1186/1897-4287-12-11 |
Pubmed ID | |
Authors |
Julián Esteban Londoño Hernández, Marcia Llacuachaqui, Gonzalo Vásquez Palacio, Juan David Figueroa, Jorge Madrid, Mauricio Lema, Robert Royer, Song Li, Garrett Larson, Jeffrey N Weitzel, Steven A Narod |
Abstract |
Approximately 5% of all breast cancers can be attributed to a mutation in the BRCA1 or BRCA2 gene. The genetic component of breast cancer in Colombia has been, for the most part, studied on cases from the Bogota region. Five different founder mutations were in two studies of breast cancer patients in the Bogota region. It is important that the frequency of mutations be established among unselected cases of breast cancer of other regions of Colombia in order to estimate the genetic burden of this cancer in Colombia and to plan genetic services. The aim of this study was to establish the mutation frequencies of the BRCA genes in breast cancer patients unselected for family history or age, from Medellin, Colombia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 69 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 18% |
Student > Master | 10 | 14% |
Student > Bachelor | 10 | 14% |
Student > Ph. D. Student | 6 | 8% |
Other | 3 | 4% |
Other | 11 | 15% |
Unknown | 18 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 27% |
Agricultural and Biological Sciences | 17 | 24% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Business, Management and Accounting | 1 | 1% |
Nursing and Health Professions | 1 | 1% |
Other | 4 | 6% |
Unknown | 19 | 27% |