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X Demographics
Mendeley readers
| Title |
Spironolactone to prevent cardiovascular events in early-stage chronic kidney disease (STOP-CKD): study protocol for a randomized controlled pilot trial
|
|---|---|
| Published in |
Trials, May 2014
|
| DOI | 10.1186/1745-6215-15-158 |
| Pubmed ID | |
| Authors |
Khai P Ng, Poorva Jain, Gurdip Heer, Val Redman, Odette L Chagoury, George Dowswell, Sheila Greenfield, Nick Freemantle, Jonathan N Townend, Paramjit S Gill, Richard J McManus, Charles J Ferro |
| Abstract |
Chronic kidney disease is associated with increased arterial stiffness even in the early stages and this is thought to be a key mediator in the pathophysiology of the increased cardiovascular risk associated with this condition. The use of low-dose spironolactone has previously been shown to improve arterial stiffness and reduce left ventricular mass safely in early-stage chronic kidney disease in the context of careful monitoring at a university hospital. However, the majority of patients with chronic kidney disease are managed by their general practitioners in the community. It is not known whether similar beneficial effects can be achieved safely using spironolactone in the primary care setting. The aim of this study is to determine whether low-dose spironolactone can safely lower arterial stiffness in patients with stage 3 chronic kidney disease in the primary care setting. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 148 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 16% |
| Student > Bachelor | 23 | 15% |
| Researcher | 21 | 14% |
| Other | 13 | 9% |
| Student > Ph. D. Student | 9 | 6% |
| Other | 22 | 15% |
| Unknown | 39 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 35% |
| Nursing and Health Professions | 17 | 11% |
| Agricultural and Biological Sciences | 8 | 5% |
| Social Sciences | 5 | 3% |
| Psychology | 5 | 3% |
| Other | 15 | 10% |
| Unknown | 48 | 32% |