Title |
Emerging therapies for severe asthma
|
---|---|
Published in |
BMC Medicine, September 2011
|
DOI | 10.1186/1741-7015-9-102 |
Pubmed ID | |
Authors |
Neil C Thomson, Rekha Chaudhuri, Mark Spears |
Abstract |
Many patients with asthma have poorly controlled symptoms, and particularly for those with severe disease, there is a clear need for improved treatments. Two recent therapies licensed for use in asthma are omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, and bronchial thermoplasty, which involves the delivery of radio frequency energy to the airways to reduce airway smooth muscle mass. In addition, there are new therapies under development for asthma that have good potential to reach the clinic in the next five years. These include biological agents targeting pro-inflammatory cytokines such as interleukin-5 and interleukin-13, inhaled ultra long-acting β2-agonists and once daily inhaled corticosteroids. In addition, drugs that block components of the arachidonic acid pathway that targets neutrophilic asthma and CRTH2 receptor antagonists that inhibit the proinflammatory actions of prostaglandin D2 may become available. We review the recent progress made in developing viable therapies for severe asthma and briefly discuss the idea that development of novel therapies for asthma is likely to increasingly involve the assessment of genotypic and/or phenotypic factors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 13% |
Argentina | 2 | 13% |
United States | 1 | 6% |
Peru | 1 | 6% |
Unknown | 10 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 4 | 25% |
Members of the public | 4 | 25% |
Scientists | 2 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Unknown | 5 | 31% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Israel | 1 | 1% |
India | 1 | 1% |
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 72 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 17% |
Other | 12 | 16% |
Student > Master | 11 | 14% |
Student > Ph. D. Student | 9 | 12% |
Student > Bachelor | 6 | 8% |
Other | 17 | 22% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 48% |
Agricultural and Biological Sciences | 14 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Engineering | 3 | 4% |
Other | 3 | 4% |
Unknown | 9 | 12% |