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Nonsteroidal anti-inflammatory drugs and their risk: a story still in development

Overview of attention for article published in Arthritis Research & Therapy, January 2013
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Nonsteroidal anti-inflammatory drugs and their risk: a story still in development
Published in
Arthritis Research & Therapy, January 2013
DOI 10.1186/ar4173
Pubmed ID

Lee S Simon


NSAIDs are anti-inflammatory, analgesic, and antipyretic agents, and they are typically used chronically to reduce pain, decrease stiffness, and improve function in patients with osteoarthritis, rheumatoid arthritis, and other forms of arthritis. Additionally, NSAIDs are also used for the more acute treatment of pain including headache, dysmenorrhea, and postoperative pain. However, NSAID use conveys potential significant adverse events that include gastrointestinal ulcers with consequential bleeding, perforation or obstruction, renal dysfunction and consequent renal failure, cardiovascular events, as well as the risk for death. Despite the many available forms of NSAIDs, including injectable as well as topical, oral dosing is the most common route, usually the one route consistently associated with chronic use and thus the one that carries the most risk. In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years. One study of a diclofenac topical liquid included an oral diclofenac comparator, and demonstrated no difference in efficacy between the two therapies in treatment for the pain of osteoarthritis in the knee.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Argentina 1 1%
Unknown 74 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 17%
Student > Master 9 12%
Researcher 6 8%
Student > Postgraduate 6 8%
Other 5 7%
Other 14 18%
Unknown 23 30%
Readers by discipline Count As %
Medicine and Dentistry 22 29%
Pharmacology, Toxicology and Pharmaceutical Science 9 12%
Agricultural and Biological Sciences 7 9%
Nursing and Health Professions 4 5%
Business, Management and Accounting 1 1%
Other 5 7%
Unknown 28 37%