Title |
MicroRNA-21 regulates stemness in cancer cells
|
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Published in |
Stem Cell Research & Therapy, September 2013
|
DOI | 10.1186/scrt321 |
Pubmed ID | |
Authors |
Hong-Yo Kang |
Abstract |
MicroRNA-21 (miR-21) functions have been linked to cancer progression and chemo- or radiotherapy resistance. While an increasing number of studies have reported a potential role of miR-21 expression in promoting growth of a small population of stem/progenitor cells, knowledge on its role as a regulator of stemness in cancers remains limited. In a previous issue of Stem Cell Research & Therapy, Chung and colleagues provide evidence that miR-21 is highly expressed in stem/progenitor populations of ovarian teratocarcinoma cells and has the potential to mediate growth and self-renewal in cancer stem/progenitor cells. Here we summarize current knowledge on miR-21 functions in human cancers and discuss how this finding provides insight into the role of miR-21 as an oncogenic regulator in stem/progenitor cell populations of human cancers. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 25% |
Student > Ph. D. Student | 3 | 19% |
Professor | 3 | 19% |
Other | 1 | 6% |
Lecturer | 1 | 6% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 31% |
Agricultural and Biological Sciences | 4 | 25% |
Medicine and Dentistry | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Materials Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 19% |