Title |
Clinical features and management of a severe paradoxical reaction associated with combined treatment of Buruli ulcer and HIV co-infection
|
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Published in |
BMC Infectious Diseases, July 2014
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DOI | 10.1186/1471-2334-14-423 |
Pubmed ID | |
Authors |
Franck Wanda, Patrick Nkemenang, Genevieve Ehounou, Marie Tchaton, Eric Comte, Laurence Toutous Trellu, Isabelle Masouyé, Vanessa Christinet, Daniel P O’Brien |
Abstract |
In West and Central Africa Buruli ulcer (BU) and HIV co-infection is increasingly recognised and management of these two diseases combined is an emerging challenge for which there is little published information. In this case we present a severe paradoxical reaction occurring after commencing antibiotic treatment for BU combined with antiretroviral therapy for HIV, and describe its clinical features and management. This includes to our knowledge the first reported use of prednisolone in Africa to manage a severe paradoxical reaction related to BU treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
United Kingdom | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 39 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 17% |
Student > Master | 7 | 17% |
Student > Bachelor | 5 | 12% |
Student > Ph. D. Student | 5 | 12% |
Student > Postgraduate | 5 | 12% |
Other | 4 | 10% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 37% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Agricultural and Biological Sciences | 5 | 12% |
Nursing and Health Professions | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Other | 4 | 10% |
Unknown | 7 | 17% |