Title |
Classification of patients with breast cancer according to Nottingham Prognostic Index highlights significant differences in immunohistochemical marker expression
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Published in |
World Journal of Surgical Oncology, August 2014
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DOI | 10.1186/1477-7819-12-243 |
Pubmed ID | |
Authors |
Fisnik Kurshumliu, Lumturije Gashi-Luci, Shahin Kadare, Mehdi Alimehmeti, Ugur Gozalan |
Abstract |
Prognosis and treatment of patients with breast carcinoma of no special type (NST) is dependent on a few established parameters, such as tumor size, histological grade, lymph node stage, expression of estrogen receptor, progesterone receptor, and HER-2/neu, and proliferation index. The original Nottingham Prognostic Index (NPI) employs a three-tiered classification system that stratifies patients with breast cancer into good, moderate, and poor prognostic groups. The aim of our study was to use robust immunohistochemical methodology for determination of ER, PR, HER-2/neu, Ki-67, p53, and Bcl-2, and to observe differences in the expression of these markers when patients are stratified according to the original, three-tiered Nottingham Prognostic Index. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 4 | 12% |
Student > Bachelor | 4 | 12% |
Student > Master | 4 | 12% |
Student > Postgraduate | 4 | 12% |
Student > Ph. D. Student | 4 | 12% |
Other | 3 | 9% |
Unknown | 11 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 18 | 53% |
Business, Management and Accounting | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 0 | 0% |
Unknown | 12 | 35% |