Title |
Functional and genetic analysis of the colon cancer network
|
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Published in |
BMC Bioinformatics, May 2014
|
DOI | 10.1186/1471-2105-15-s6-s6 |
Pubmed ID | |
Authors |
Frank Emmert-Streib, Ricardo de Matos Simoes, Galina Glazko, Simon McDade, Benjamin Haibe-Kains, Andreas Holzinger, Matthias Dehmer, Frederick Charles Campbell |
Abstract |
Cancer is a complex disease that has proven to be difficult to understand on the single-gene level. For this reason a functional elucidation needs to take interactions among genes on a systems-level into account. In this study, we infer a colon cancer network from a large-scale gene expression data set by using the method BC3Net. We provide a structural and a functional analysis of this network and also connect its molecular interaction structure with the chromosomal locations of the genes enabling the definition of cis- and trans-interactions. Furthermore, we investigate the interaction of genes that can be found in close neighborhoods on the chromosomes to gain insight into regulatory mechanisms. To our knowledge this is the first study analyzing the genome-scale colon cancer network. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Bulgaria | 1 | 2% |
Austria | 1 | 2% |
Unknown | 43 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 28% |
Student > Ph. D. Student | 8 | 17% |
Student > Bachelor | 4 | 9% |
Professor > Associate Professor | 4 | 9% |
Student > Master | 4 | 9% |
Other | 6 | 13% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 28% |
Computer Science | 10 | 22% |
Medicine and Dentistry | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 6 | 13% |
Unknown | 10 | 22% |