Title |
Long-lasting anxiolytic effect of neural precursor cells freshly prepared but not neurosphere-derived cell transplantation in newborn rats
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Published in |
BMC Neuroscience, August 2014
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DOI | 10.1186/1471-2202-15-94 |
Pubmed ID | |
Authors |
Simone Amaro Alves Romariz, Daisyléa de Souza Paiva, Maria Fernanda Valente, Gabriela Filoso Barnabé, Roberto Frussa-Filho, Regina Cláudia Barbosa-Silva, Maria Elisa Calcagnotto, Beatriz Monteiro Longo |
Abstract |
The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into GABAergic interneurons and modify the inhibitory tone in the host brain. Currently, two methods have been reported for obtaining MGE precursor cells for transplantation: fresh and neurosphere dissociated cells. Here, we investigated the effects generated by transplantation of the two types of cell preparations on anxiety behavior in rats. |
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