Title |
MiR-206-mediated dynamic mechanism of the mammalian circadian clock
|
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Published in |
BMC Systems Biology, September 2011
|
DOI | 10.1186/1752-0509-5-141 |
Pubmed ID | |
Authors |
Wei Zhou, Yan Li, Xia Wang, Lianqi Wu, Yonghua Wang |
Abstract |
As a group of highly conserved small non-coding RNAs with a length of 21~23 nucleotides, microRNAs (miRNAs) regulate the gene expression post-transcriptionally by base pairing with the partial or full complementary sequences in target mRNAs, thus resulting in the repression of mRNA translation and the acceleration of mRNA degradation. Recent work has revealed that miRNAs are essential for the development and functioning of the skeletal muscles where they are. In particular, miR-206 has not only been identified as the only miRNA expressed in skeletal muscles, but also exhibited crucial roles in regulation of the muscle development. Although miRNAs are known to regulate various biological processes ranging from development to cancer, much less is known about their role in the dynamic regulation of the mammalian circadian clock. |
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Geographical breakdown
Country | Count | As % |
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Sweden | 1 | 33% |
Australia | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 2% |
United States | 1 | 2% |
Sweden | 1 | 2% |
Italy | 1 | 2% |
Unknown | 48 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 21% |
Researcher | 11 | 21% |
Student > Bachelor | 3 | 6% |
Professor | 3 | 6% |
Other | 3 | 6% |
Other | 5 | 10% |
Unknown | 16 | 31% |
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Biochemistry, Genetics and Molecular Biology | 11 | 21% |
Computer Science | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Psychology | 1 | 2% |
Other | 2 | 4% |
Unknown | 17 | 33% |