Title |
The extracellular matrix protein mindin as a novel adjuvant elicits stronger immune responses for rBAG1, rSRS4 and rSRS9 antigens of Toxoplasma gondiiin BALB/c mice
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Published in |
BMC Infectious Diseases, August 2014
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DOI | 10.1186/1471-2334-14-429 |
Pubmed ID | |
Authors |
Xiaojing Sun, Mei Mei, Xu Zhang, Fusong Han, Boyin Jia, Xiaoyan Wei, Zhiguang Chang, Huijun Lu, Jigang Yin, Qijun Chen, Ning Jiang |
Abstract |
Vaccines are the most effective agents to control infections. However, recombinant vaccines often do not elicit strong immune responses. Protein antigens combined with proper adjuvants have been widely used to induce immune responses, especially the humoral immune responses, against various pathogens, including parasites. The extracellular matrix protein mindin has been recognised as an immune facilitator for initiating innate immune responses. It has therefore been expected to be a potentially potent adjuvant in the development of novel vaccines. The aim of this study was to investigate whether mindin could facilitate the induction of antigen-specific immune responses to recombinant antigens (rBAG1, rSRS4 and rSRS9) of Toxoplasma gondii in BALB/c mice. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 23% |
Student > Master | 6 | 23% |
Researcher | 4 | 15% |
Student > Bachelor | 2 | 8% |
Professor | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 31% |
Medicine and Dentistry | 4 | 15% |
Veterinary Science and Veterinary Medicine | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Energy | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 19% |