Title |
Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice
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Published in |
Respiratory Research, August 2014
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DOI | 10.1186/s12931-014-0092-3 |
Pubmed ID | |
Authors |
Shingo Noguchi, Kazuhiro Yatera, Ke-Yong Wang, Keishi Oda, Kentarou Akata, Kei Yamasaki, Toshinori Kawanami, Hiroshi Ishimoto, Yumiko Toyohira, Hiroaki Shimokawa, Nobuyuki Yanagihara, Masato Tsutsui, Hiroshi Mukae |
Abstract |
Increased expression of nitric oxide synthase (NOS) and an increase in plasma nitrite plus nitrate (NOx) have been reported in patients with pulmonary fibrosis, suggesting that nitric oxide (NO) plays an important role in its development. However, the roles of the entire NO and NOS system in the pathogenesis of pulmonary fibrosis still remain to be fully elucidated. The aim of the present study is to clarify the roles of NO and the NOS system in pulmonary fibrosis by using the mice lacking all three NOS isoforms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 19% |
Student > Bachelor | 3 | 11% |
Student > Ph. D. Student | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Other | 1 | 4% |
Other | 3 | 11% |
Unknown | 10 | 37% |
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Medicine and Dentistry | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 2 | 7% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 2 | 7% |
Unknown | 13 | 48% |