Title |
Selective internal radiotherapy (SIRT) versus transarterial chemoembolization (TACE) for the treatment of intrahepatic cholangiocellular carcinoma (CCC): study protocol for a randomized controlled trial
|
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Published in |
Trials, August 2014
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DOI | 10.1186/1745-6215-15-311 |
Pubmed ID | |
Authors |
Roman Kloeckner, Christian Ruckes, Kai Kronfeld, Marcus Alexander Wörns, Arndt Weinmann, Peter Robert Galle, Hauke Lang, Gerd Otto, Waltraud Eichhorn, Mathias Schreckenberger, Christoph Dueber, Michael Bernhard Pitton |
Abstract |
Cholangiocellular carcinoma is the second most common primary liver cancer after hepatocellular carcinoma. Over the last 30 years, the incidence of intrahepatic cholangiocellular carcinoma has risen continuously worldwide. Meanwhile, the intrahepatic cholangiocellular carcinoma has become more common than the extrahepatic growth type and currently accounts for 10-15% of all primary hepatic malignancies. Intrahepatic cholangiocellular carcinoma is typically diagnosed in advanced stages due to late clinical symptoms and an absence of classic risk factors. A late diagnosis precludes curative surgical resection. There is evidence that transarterial chemoembolization leads to better local tumor control and prolongs survival compared to systemic chemotherapy. New data indicates that selective internal radiotherapy, also referred to as radioembolization, provides promising results for treating intrahepatic cholangiocellular carcinoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 60 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 12 | 19% |
Researcher | 8 | 13% |
Student > Ph. D. Student | 7 | 11% |
Student > Doctoral Student | 4 | 6% |
Student > Bachelor | 4 | 6% |
Other | 10 | 16% |
Unknown | 17 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 52% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Nursing and Health Professions | 2 | 3% |
Engineering | 2 | 3% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 3 | 5% |
Unknown | 18 | 29% |