Title |
The VITAH Trial Vitamin D supplementation and cardiac autonomic tone in hemodialysis: a blinded, randomized controlled trial
|
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Published in |
BMC Nephrology, August 2014
|
DOI | 10.1186/1471-2369-15-129 |
Pubmed ID | |
Authors |
Michelle C Mann, Derek V Exner, Brenda R Hemmelgarn, David A Hanley, Tanvir C Turin, Jennifer M MacRae, Sofia B Ahmed |
Abstract |
Patients with end-stage kidney disease (ESKD) have a high rate of mortality and specifically an increased risk of sudden cardiac death (SCD). Impaired cardiac autonomic tone is associated with elevated risk of SCD. Moreover, patients with ESKD are often vitamin D deficient, which we have shown may be linked to autonomic dysfunction in humans. To date, it is not known whether vitamin D supplementation normalizes cardiac autonomic function in the high-risk ESKD population. The VITamin D supplementation and cardiac Autonomic tone in Hemodialysis (VITAH) randomized trial will determine whether intensive vitamin D supplementation therapies improve cardiac autonomic tone to a greater extent than conventional vitamin D supplementation regimens in ESKD patients requiring chronic hemodialysis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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New Zealand | 1 | 1% |
Unknown | 73 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 16% |
Student > Master | 9 | 12% |
Researcher | 6 | 8% |
Student > Postgraduate | 6 | 8% |
Lecturer | 5 | 7% |
Other | 16 | 22% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 34% |
Nursing and Health Professions | 5 | 7% |
Psychology | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Neuroscience | 2 | 3% |
Other | 11 | 15% |
Unknown | 23 | 31% |