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Mendeley readers
Attention Score in Context
| Title |
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching
|
|---|---|
| Published in |
Epigenetics & Chromatin, July 2014
|
| DOI | 10.1186/1756-8935-7-14 |
| Pubmed ID | |
| Authors |
Martin Philpott, Catherine M Rogers, Clarence Yapp, Chris Wells, Jean-Philippe Lambert, Claire Strain-Damerell, Nicola A Burgess-Brown, Anne-Claude Gingras, Stefan Knapp, Susanne Müller |
| Abstract |
Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of chromatin-related functions. Moreover, they are increasingly being recognised as important mediators of a wide range of diseases. The first potent and selective bromodomain inhibitors are beginning to be described, but the diverse or unknown functions of bromodomain-containing proteins present challenges to systematically demonstrating cellular efficacy and selectivity for these inhibitors. Here we assess the viability of fluorescence recovery after photobleaching (FRAP) assays as a target agnostic method for the direct visualisation of an on-target effect of bromodomain inhibitors in living cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Denmark | 1 | 1% |
| Argentina | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 93 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 33% |
| Researcher | 21 | 22% |
| Student > Master | 10 | 10% |
| Professor | 8 | 8% |
| Student > Bachelor | 5 | 5% |
| Other | 14 | 14% |
| Unknown | 7 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 29 | 30% |
| Agricultural and Biological Sciences | 27 | 28% |
| Biochemistry, Genetics and Molecular Biology | 23 | 24% |
| Medicine and Dentistry | 5 | 5% |
| Computer Science | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 9 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2014.
All research outputs
#20,233,547
of 22,759,618 outputs
Outputs from Epigenetics & Chromatin
#522
of 566 outputs
Outputs of similar age
#190,876
of 226,372 outputs
Outputs of similar age from Epigenetics & Chromatin
#7
of 12 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,372 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.