↓ Skip to main content

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

Overview of attention for article published in Epigenetics & Chromatin, July 2014
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
66 Dimensions

Readers on

mendeley
97 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching
Published in
Epigenetics & Chromatin, July 2014
DOI 10.1186/1756-8935-7-14
Pubmed ID
Authors

Martin Philpott, Catherine M Rogers, Clarence Yapp, Chris Wells, Jean-Philippe Lambert, Claire Strain-Damerell, Nicola A Burgess-Brown, Anne-Claude Gingras, Stefan Knapp, Susanne Müller

Abstract

Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of chromatin-related functions. Moreover, they are increasingly being recognised as important mediators of a wide range of diseases. The first potent and selective bromodomain inhibitors are beginning to be described, but the diverse or unknown functions of bromodomain-containing proteins present challenges to systematically demonstrating cellular efficacy and selectivity for these inhibitors. Here we assess the viability of fluorescence recovery after photobleaching (FRAP) assays as a target agnostic method for the direct visualisation of an on-target effect of bromodomain inhibitors in living cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Denmark 1 1%
Argentina 1 1%
Canada 1 1%
Unknown 93 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 33%
Researcher 21 22%
Student > Master 10 10%
Professor 8 8%
Student > Bachelor 5 5%
Other 14 14%
Unknown 7 7%
Readers by discipline Count As %
Chemistry 29 30%
Agricultural and Biological Sciences 28 29%
Biochemistry, Genetics and Molecular Biology 22 23%
Medicine and Dentistry 5 5%
Computer Science 2 2%
Other 2 2%
Unknown 9 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2014.
All research outputs
#3,295,420
of 4,115,913 outputs
Outputs from Epigenetics & Chromatin
#107
of 124 outputs
Outputs of similar age
#82,006
of 102,675 outputs
Outputs of similar age from Epigenetics & Chromatin
#5
of 5 outputs
Altmetric has tracked 4,115,913 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 124 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,675 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.