Title |
Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs
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Published in |
BMC Genomics, August 2014
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DOI | 10.1186/1471-2164-15-653 |
Pubmed ID | |
Authors |
Long Jin, Zhi Jiang, Yudong Xia, Ping’er Lou, Lei Chen, Hongmei Wang, Lu Bai, Yanmei Xie, Yihui Liu, Wei Li, Bangsheng Zhong, Junfang Shen, An’an Jiang, Li Zhu, Jinyong Wang, Xuewei Li, Mingzhou Li |
Abstract |
Age-related physiological, biochemical and functional changes in mammalian skeletal muscle have been shown to begin at the mid-point of the lifespan. However, the underlying changes in DNA methylation that occur during this turning point of the muscle aging process have not been clarified. To explore age-related genomic methylation changes in skeletal muscle, we employed young (0.5 years old) and middle-aged (7 years old) pigs as models to survey genome-wide DNA methylation in the longissimus dorsi muscle using a methylated DNA immunoprecipitation sequencing approach. |
X Demographics
Geographical breakdown
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Norway | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 1% |
Unknown | 69 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 29% |
Researcher | 14 | 20% |
Student > Master | 8 | 11% |
Student > Bachelor | 3 | 4% |
Student > Postgraduate | 3 | 4% |
Other | 9 | 13% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 20% |
Engineering | 3 | 4% |
Sports and Recreations | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Other | 7 | 10% |
Unknown | 15 | 21% |