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The hunt for protective correlates of immunity to Plasmodium falciparummalaria

Overview of attention for article published in BMC Medicine, August 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
1 X user

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52 Mendeley
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Title
The hunt for protective correlates of immunity to Plasmodium falciparummalaria
Published in
BMC Medicine, August 2014
DOI 10.1186/s12916-014-0134-1
Pubmed ID
Authors

Ann M Moormann, V Ann Stewart

Abstract

Determining an immunologic correlate of protection against Plasmodium falciparum malaria has been the holy grail of natural infection studies, and sought after as an endpoint for malaria vaccine trials. An in vitro assay that provides an accurate and precise assessment of protective immunity to malaria would make smaller, short-duration studies feasible, rather than the currently powered study designs that use morbidity or mortality as outcomes. Such a biomarker would be especially desirable in situations where malaria control measures that result in decreases in clinical endpoints and putatively waning protective immunity have been implemented. In an article published in BMC Medicine, Osier and colleagues addressed this problem, and demonstrated that antibodies promoting opsonic phagocytosis of merozoites provide a functional link between antigen-specific responses and protection. Understanding the mechanisms conferring protection against malaria not only improves our knowledge of basic human immunology, but promises to help in the design of an effective malaria vaccine.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Burkina Faso 1 2%
Spain 1 2%
Portugal 1 2%
Unknown 49 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 31%
Researcher 12 23%
Student > Bachelor 6 12%
Student > Master 6 12%
Student > Postgraduate 2 4%
Other 4 8%
Unknown 6 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 25%
Medicine and Dentistry 10 19%
Immunology and Microbiology 9 17%
Biochemistry, Genetics and Molecular Biology 7 13%
Computer Science 1 2%
Other 3 6%
Unknown 9 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2014.
All research outputs
#3,945,746
of 22,759,618 outputs
Outputs from BMC Medicine
#1,987
of 3,413 outputs
Outputs of similar age
#39,484
of 230,503 outputs
Outputs of similar age from BMC Medicine
#35
of 58 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,413 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.5. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.