Title |
A systems biology approach identified different regulatory networks targeted by KSHV miR-K12-11 in B cells and endothelial cells
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Published in |
BMC Genomics, August 2014
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DOI | 10.1186/1471-2164-15-668 |
Pubmed ID | |
Authors |
Yajie Yang, Isaac W Boss, Lauren M McIntyre, Rolf Renne |
Abstract |
Kaposi's sarcoma associated herpes virus (KSHV) is associated with tumors of endothelial and lymphoid origin. During latent infection, KSHV expresses miR-K12-11, an ortholog of the human tumor gene hsa-miR-155. Both gene products are microRNAs (miRNAs), which are important post-transcriptional regulators that contribute to tissue specific gene expression. Advances in target identification technologies and molecular interaction databases have allowed a systems biology approach to unravel the gene regulatory networks (GRNs) triggered by miR-K12-11 in endothelial and lymphoid cells. Understanding the tissue specific function of miR-K12-11 will help to elucidate underlying mechanisms of KSHV pathogenesis. |
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