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A systems biology approach identified different regulatory networks targeted by KSHV miR-K12-11 in B cells and endothelial cells

Overview of attention for article published in BMC Genomics, August 2014
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Title
A systems biology approach identified different regulatory networks targeted by KSHV miR-K12-11 in B cells and endothelial cells
Published in
BMC Genomics, August 2014
DOI 10.1186/1471-2164-15-668
Pubmed ID
Authors

Yajie Yang, Isaac W Boss, Lauren M McIntyre, Rolf Renne

Abstract

Kaposi's sarcoma associated herpes virus (KSHV) is associated with tumors of endothelial and lymphoid origin. During latent infection, KSHV expresses miR-K12-11, an ortholog of the human tumor gene hsa-miR-155. Both gene products are microRNAs (miRNAs), which are important post-transcriptional regulators that contribute to tissue specific gene expression. Advances in target identification technologies and molecular interaction databases have allowed a systems biology approach to unravel the gene regulatory networks (GRNs) triggered by miR-K12-11 in endothelial and lymphoid cells. Understanding the tissue specific function of miR-K12-11 will help to elucidate underlying mechanisms of KSHV pathogenesis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 31%
Researcher 5 16%
Student > Doctoral Student 3 9%
Professor > Associate Professor 3 9%
Student > Master 3 9%
Other 6 19%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 44%
Biochemistry, Genetics and Molecular Biology 7 22%
Veterinary Science and Veterinary Medicine 2 6%
Medicine and Dentistry 2 6%
Unspecified 1 3%
Other 4 13%
Unknown 2 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2015.
All research outputs
#18,375,478
of 22,759,618 outputs
Outputs from BMC Genomics
#8,167
of 10,637 outputs
Outputs of similar age
#164,408
of 230,503 outputs
Outputs of similar age from BMC Genomics
#124
of 186 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,637 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,503 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.