Title |
Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial
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Published in |
Trials, June 2014
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DOI | 10.1186/1745-6215-15-258 |
Pubmed ID | |
Authors |
Angela Pushpa-Rajah, Lucy Bradshaw, Jon Dorling, Gill Gyte, Eleanor J Mitchell, Jim Thornton, Lelia Duley |
Abstract |
Preterm birth is the most important single determinant of adverse outcome in the United Kingdom; one in every 70 babies (1.4%) is born before 32 weeks (very preterm), yet these births account for over half of infant deaths.Deferring cord clamping allows blood flow between baby and placenta to continue for a short time. This often leads to increased neonatal blood volume at birth and may allow longer for transition to the neonatal circulation. Optimal timing for clamping the cord remains uncertain, however. The Cochrane Review suggests that deferring umbilical cord clamping for preterm births may improve outcome, but larger studies reporting substantive outcomes and with long-term follow-up are needed. Studies of the physiology of placental transfusion suggest that flow in the umbilical cord at very preterm birth may continue for several minutes. This pilot trial aims to assess the feasibility of conducting a large randomised trial comparing immediate and deferred cord clamping in the UK. |
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Kuwait | 1 | 17% |
Kenya | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
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Scientists | 2 | 33% |
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Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Bachelor | 10 | 10% |
Student > Postgraduate | 8 | 8% |
Researcher | 7 | 7% |
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Other | 5 | 5% |
Unknown | 32 | 33% |