You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer
|
|---|---|
| Published in |
Journal of Biomedical Science, August 2014
|
| DOI | 10.1186/s12929-014-0073-3 |
| Pubmed ID | |
| Authors |
Nader Mansour Samaei, Yaghoub Yazdani, Reza Alizadeh-Navaei, Hossein Azadeh, Touraj Farazmandfar |
| Abstract |
BackgroundAberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer. In this study, we decided to identify promoter methylation status of ten genes encoding WNT negative regulators, and measure the expression of DNMT1 enzyme in colorectal cancer samples.ResultsAberrant methylation of APC gene was statistically significant associated with age over 50 (p¿=¿0.017), DDK3 with male (p¿<¿0.0001), SFRP4, WIF1, and WNT5a with increasing tumor stage (p¿=¿0.004, p¿=¿0.029, and p¿=¿0.004), SFRP4 and WIF1 with tumor differentiation (p¿=¿0.009 and p¿=¿0.031) and SFRP2 and SFRP5 with histological type (p¿=¿0.001 and p¿=¿0.025). The increasing number of methylated genes correlated with the expression levels of the DNMT1 mRNA.ConclusionsThe rate of gene promoter methylation of WNT pathway regulators is high in colorectal cancer cells. Hyper-methylation is associated with increased expression of the DNMT1 enzyme. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 19% |
| Researcher | 10 | 18% |
| Other | 7 | 12% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 5 | 9% |
| Other | 9 | 16% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 28% |
| Agricultural and Biological Sciences | 14 | 25% |
| Medicine and Dentistry | 10 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 11 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2014.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Journal of Biomedical Science
#969
of 1,101 outputs
Outputs of similar age
#207,982
of 242,347 outputs
Outputs of similar age from Journal of Biomedical Science
#13
of 15 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,347 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.