Title |
Lipoteichoic acid is an important microbe-associated molecular pattern of Lactobacillus rhamnosus GG
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Published in |
Microbial Cell Factories, December 2012
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DOI | 10.1186/1475-2859-11-161 |
Pubmed ID | |
Authors |
Ingmar JJ Claes, Marijke E Segers, Tine LA Verhoeven, Michiel Dusselier, Bert F Sels, Sigrid CJ De Keersmaecker, Jos Vanderleyden, Sarah Lebeer |
Abstract |
Probiotic bacteria are increasingly used as immunomodulatory agents. Yet detailed molecular knowledge on the immunomodulatory molecules of these bacteria is lagging behind. Lipoteichoic acid (LTA) is considered a major microbe-associated molecular pattern (MAMP) of Gram-positive bacteria. However, many details and quantitative data on its immune signalling capacity are still unknown, especially in beneficial bacteria. Recently, we have demonstrated that a dltD mutant of the model probiotic Lactobacillus rhamnosus GG (LGG), having modified LTA molecules, has an enhanced probiotic efficacy in a DSS-induced colitis model as compared to wild-type. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 120 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 18% |
Researcher | 21 | 18% |
Student > Master | 12 | 10% |
Student > Doctoral Student | 9 | 8% |
Student > Postgraduate | 5 | 4% |
Other | 13 | 11% |
Unknown | 38 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 21% |
Immunology and Microbiology | 22 | 18% |
Biochemistry, Genetics and Molecular Biology | 13 | 11% |
Medicine and Dentistry | 10 | 8% |
Chemistry | 4 | 3% |
Other | 9 | 8% |
Unknown | 37 | 31% |