Title |
Differential effects of Radix Paeoniae Rubra (Chishao) on cytokine and chemokine expression inducible by mycobacteria
|
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Published in |
Chinese Medicine, March 2011
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DOI | 10.1186/1749-8546-6-14 |
Pubmed ID | |
Authors |
Liangjie Wang, Cindy Lai Hung Yang, Terry Cho Tsun Or, Gang Chen, Jian Zhou, James Chun Tsun Li, Allan Sik Yin Lau |
Abstract |
Upon initial infection with mycobacteria, macrophages secrete multiple cytokines and chemokines, including interleukin-6 (IL-6), IL-8 and tumor necrosis factor-α (TNF-α), to mediate host immune responses against the pathogen. Mycobacteria also induce the production of IL-10 via PKR activation in primary human monocytes and macrophages. As an anti-inflammatory cytokine, over-expression of IL-10 may contribute to mycobacterial evasion of the host immunity. Radix Paeoniae Rubra (RPR, Chishao), a Chinese medicinal herb with potentials of anti-inflammatory, hepatoprotective and neuroprotective effects, is used to treat tuberculosis. This study investigates the immunoregulatory effects of RPR on primary human blood macrophages (PBMac) during mycobacterial infection. |
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Demographic breakdown
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Other | 1 | 5% |
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