Title |
Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle
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Published in |
Nutrition & Metabolism, July 2014
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DOI | 10.1186/1743-7075-11-32 |
Pubmed ID | |
Authors |
Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto, Tohru Sakai |
Abstract |
Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose, lipid, and energy metabolism in mice with high-fat diet-induced obesity and db/db diabetic mice. In our current study, we show that sudachitin improves metabolism and stimulates mitochondrial biogenesis, thereby increasing energy expenditure and reducing weight gain. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 50% |
United States | 1 | 25% |
Spain | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 66 | 97% |
Demographic breakdown
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Student > Ph. D. Student | 11 | 16% |
Student > Bachelor | 10 | 15% |
Student > Master | 9 | 13% |
Student > Doctoral Student | 6 | 9% |
Researcher | 5 | 7% |
Other | 15 | 22% |
Unknown | 12 | 18% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 8 | 12% |
Medicine and Dentistry | 8 | 12% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Chemistry | 4 | 6% |
Other | 11 | 16% |
Unknown | 21 | 31% |