Title |
Regulatory and coding genome regions are enriched for trait associated variants in dairy and beef cattle
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Published in |
BMC Genomics, June 2014
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DOI | 10.1186/1471-2164-15-436 |
Pubmed ID | |
Authors |
Lambros Koufariotis, Yi-Ping Phoebe Chen, Sunduimijid Bolormaa, Ben J Hayes |
Abstract |
In livestock, as in humans, the number of genetic variants that can be tested for association with complex quantitative traits, or used in genomic predictions, is increasing exponentially as whole genome sequencing becomes more common. The power to identify variants associated with traits, particularly those of small effects, could be increased if certain regions of the genome were known a priori to be enriched for associations. Here, we investigate whether twelve genomic annotation classes were enriched or depleted for significant associations in genome wide association studies for complex traits in beef and dairy cattle. We also describe a variance component approach to determine the proportion of genetic variance captured by each annotation class. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 33% |
Student > Ph. D. Student | 14 | 29% |
Student > Master | 4 | 8% |
Other | 3 | 6% |
Student > Doctoral Student | 1 | 2% |
Other | 2 | 4% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 28 | 58% |
Biochemistry, Genetics and Molecular Biology | 9 | 19% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Medicine and Dentistry | 1 | 2% |
Unknown | 9 | 19% |