Title |
Chikungunya triggers an autophagic process which promotes viral replication
|
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Published in |
Virology Journal, September 2011
|
DOI | 10.1186/1743-422x-8-432 |
Pubmed ID | |
Authors |
Pascale Krejbich-Trotot, Bernard Gay, Ghislaine Li-Pat-Yuen, Jean-Jacques Hoarau, Marie-Christine Jaffar-Bandjee, Laurence Briant, Philippe Gasque, Mélanie Denizot |
Abstract |
Chikungunya Virus (ChikV) surprised by a massive re-emerging outbreak in Indian Ocean in 2006, reaching Europe in 2007 and exhibited exceptional severe physiopathology in infants and elderly patients. In this context, it is important to analyze the innate immune host responses triggered against ChikV. Autophagy has been shown to be an important component of the innate immune response and is involved in host defense elimination of different pathogens. However, the autophagic process was recently observed to be hijacked by virus for their own replication. Here we provide the first evidence that hallmarks of autophagy are specifically found in HEK.293 infected cells and are involved in ChikV replication. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Italy | 1 | <1% |
Unknown | 133 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 21% |
Student > Master | 21 | 15% |
Researcher | 16 | 12% |
Student > Bachelor | 16 | 12% |
Student > Postgraduate | 8 | 6% |
Other | 22 | 16% |
Unknown | 25 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 40 | 29% |
Immunology and Microbiology | 18 | 13% |
Biochemistry, Genetics and Molecular Biology | 18 | 13% |
Medicine and Dentistry | 11 | 8% |
Neuroscience | 3 | 2% |
Other | 16 | 12% |
Unknown | 31 | 23% |