Title |
Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis
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Published in |
BMC Medicine, September 2017
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DOI | 10.1186/s12916-017-0930-5 |
Pubmed ID | |
Authors |
Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E. Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sundén Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J. Giamarellos-Bourboulis, on behalf of the Hellenic Sepsis Study Group |
Abstract |
A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to investigate the frequency of MALS and to develop a biomarker of diagnosis and prognosis. Patients with infections and systemic inflammatory response syndrome were assigned to one test cohort (n = 3417) and a validation cohort (n = 1704). MALS was diagnosed for patients scoring positive either for the hemophagocytic syndrome score and/or having both hepatobiliary dysfunction and disseminated intravascular coagulation. Logistic regression analysis was used to estimate the predictive value of MALS for 10-day mortality in both cohorts. Ferritin, sCD163, IL-6, IL-10, IL-18, interferon gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α) were measured in the blood the first 24 h; ferritin measurements were repeated in 747 patients on day 3. The frequency of MALS was 3.7% and 4.3% in the test and the validation cohort, respectively. In both cohorts, MALS was an independent risk factor for 10-day mortality. A ferritin level above 4420 ng/ml was accompanied by 66.7% and 66% mortality after 28 days, respectively. Ferritin levels above 4420 ng/ml were associated with an increase of IL-6, IL-18, INF-γ, and sCD163 and a decreased IL-10/TNF-α ratio, indicating predominance of pro-inflammatory phenomena. Any less than 15% decrease of ferritin on day 3 was associated with more than 90% sensitivity for unfavorable outcome after 10 days. This high mortality risk was also validated in an independent Swedish cohort (n = 109). MALS is an independent life-threatening entity in sepsis. Ferritin measurements can provide early diagnosis of MALS and may allow for specific treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 7 | 47% |
Ireland | 2 | 13% |
Japan | 1 | 7% |
France | 1 | 7% |
Colombia | 1 | 7% |
Malaysia | 1 | 7% |
Unknown | 2 | 13% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 67% |
Practitioners (doctors, other healthcare professionals) | 4 | 27% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 137 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 13% |
Student > Ph. D. Student | 15 | 11% |
Other | 12 | 9% |
Student > Bachelor | 12 | 9% |
Student > Doctoral Student | 11 | 8% |
Other | 27 | 20% |
Unknown | 42 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 56 | 41% |
Biochemistry, Genetics and Molecular Biology | 7 | 5% |
Immunology and Microbiology | 7 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 12 | 9% |
Unknown | 46 | 34% |