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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
|
|---|---|
| Published in |
Diabetology & Metabolic Syndrome, July 2014
|
| DOI | 10.1186/1758-5996-6-80 |
| Pubmed ID | |
| Authors |
Marilia Brito Gomes, Carlos Antonio Negrato |
| Abstract |
Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria's oxidative metabolism. It is believed that alpha-lipoic acid or its reduced form, dihydrolipoic acid have many biochemical functions acting as biological antioxidants, as metal chelators, reducers of the oxidized forms of other antioxidant agents such as vitamin C and E, and modulator of the signaling transduction of several pathways. These above-mentioned actions have been shown in experimental studies emphasizing the use of alpha-lipoic acid as a potential therapeutic agent for many chronic diseases with great epidemiological as well economic and social impact such as brain diseases and cognitive dysfunctions like Alzheimer disease, obesity, nonalcoholic fatty liver disease, burning mouth syndrome, cardiovascular disease, hypertension, some types of cancer, glaucoma and osteoporosis. Many conflicting data have been found concerning the clinical use of alpha-lipoic acid in the treatment of diabetes and of diabetes-related chronic complications such as retinopathy, nephropathy, neuropathy, wound healing and diabetic cardiovascular autonomic neuropathy. The most frequent clinical condition in which alpha-lipoic acid has been studied was in the management of diabetic peripheral neuropathy in patients with type 1 as well type 2 diabetes. Considering that oxidative stress, a imbalance between pro and antioxidants with excessive production of reactive oxygen species, is a factor in the development of many diseases and that alpha-lipoic acid, a natural thiol antioxidant, has been shown to have beneficial effects on oxidative stress parameters in various tissues we wrote this article in order to make an up-to-date review of current thinking regarding alpha-lipoic acid and its use as an antioxidant drug therapy for a myriad of diseases that could have potential benefits from its use. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 36% |
| Spain | 2 | 18% |
| United Kingdom | 1 | 9% |
| Czechia | 1 | 9% |
| Unknown | 3 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Scientists | 1 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 336 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Russia | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 329 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 55 | 16% |
| Student > Master | 44 | 13% |
| Researcher | 38 | 11% |
| Student > Ph. D. Student | 23 | 7% |
| Other | 22 | 7% |
| Other | 58 | 17% |
| Unknown | 96 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 78 | 23% |
| Agricultural and Biological Sciences | 34 | 10% |
| Biochemistry, Genetics and Molecular Biology | 30 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 7% |
| Nursing and Health Professions | 19 | 6% |
| Other | 46 | 14% |
| Unknown | 104 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 108. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2024.
All research outputs
#384,026
of 25,305,422 outputs
Outputs from Diabetology & Metabolic Syndrome
#9
of 792 outputs
Outputs of similar age
#3,270
of 235,678 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#1
of 18 outputs
Altmetric has tracked 25,305,422 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 792 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,678 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.