Title |
Correlation between ERK1 and STAT3 expression and chemoresistance in patients with conventional osteosarcoma
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Published in |
BMC Cancer, August 2014
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DOI | 10.1186/1471-2407-14-606 |
Pubmed ID | |
Authors |
Sébastien Salas, Carine Jiguet-Jiglaire, Loic Campion, Catherine Bartoli, Frédéric Frassineti, Jean-Laurent Deville, André Maues De Paula, Fabien Forest, Pascal Jézéquel, Jean-Claude Gentet, Corinne Bouvier |
Abstract |
The standard therapy regimen of conventional osteosarcoma includes neoadjuvant chemotherapy followed by surgical resection and postoperative chemotherapy. The percentage of necrotic tissue following induction chemotherapy is assessed by using the Huvos grading system, which classifies patients as "poor responders" (PR) and "good responders" (GR). The aim of this study was to identify molecular markers expressed differentially between good and poor responders to neoadjuvant chemotherapy in order to predict the response to chemotherapy in conventional osteosarcomas before beginning treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 26% |
Other | 2 | 11% |
Student > Doctoral Student | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Professor | 2 | 11% |
Other | 3 | 16% |
Unknown | 3 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 37% |
Medicine and Dentistry | 5 | 26% |
Mathematics | 1 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Computer Science | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 16% |