Title |
The research on endothelial function in women and men at risk for cardiovascular disease (REWARD) study: methodology
|
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Published in |
BMC Cardiovascular Disorders, August 2011
|
DOI | 10.1186/1471-2261-11-50 |
Pubmed ID | |
Authors |
Simon L Bacon, Kim L Lavoie, André Arsenault, Jocelyn Dupuis, Louise Pilote, Catherine Laurin, Jennifer Gordon, Denyse Gautrin, Alain Vadeboncoeur |
Abstract |
Endothelial function has been shown to be a highly sensitive marker for the overall cardiovascular risk of an individual. Furthermore, there is evidence of important sex differences in endothelial function that may underlie the differential presentation of cardiovascular disease (CVD) in women relative to men. As such, measuring endothelial function may have sex-specific prognostic value for the prediction of CVD events, thus improving risk stratification for the overall prediction of CVD in both men and women. The primary objective of this study is to assess the clinical utility of the forearm hyperaemic reactivity (FHR) test (a proxy measure of endothelial function) for the prediction of CVD events in men vs. women using a novel, noninvasive nuclear medicine -based approach. It is hypothesised that: 1) endothelial dysfunction will be a significant predictor of 5-year CVD events independent of baseline stress test results, clinical, demographic, and psychological variables in both men and women; and 2) endothelial dysfunction will be a better predictor of 5-year CVD events in women compared to men. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 1% |
Austria | 1 | 1% |
Unknown | 75 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 17% |
Student > Bachelor | 13 | 17% |
Researcher | 10 | 13% |
Professor | 6 | 8% |
Student > Doctoral Student | 5 | 6% |
Other | 12 | 16% |
Unknown | 18 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 27% |
Agricultural and Biological Sciences | 6 | 8% |
Nursing and Health Professions | 5 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Psychology | 4 | 5% |
Other | 12 | 16% |
Unknown | 25 | 32% |